Glutamate and reinstatement
نویسندگان
چکیده
منابع مشابه
Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
Modafinil may be useful for treating stimulant abuse, but the mechanisms by which it acts to do so are unknown. Indeed, a primary effect of modafinil is to inhibit dopamine transport, which typically promotes rather than inhibits motivated behavior. Therefore, we examined the role of nucleus accumbens extracellular glutamate and the group II metabotropic glutamate receptor (mGluR2/3) in modafin...
متن کاملCRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking.
Stress can reinstate cocaine seeking through an interaction between the stress hormone corticotropin releasing factor (CRF) and glutamate release onto dopamine neurons in the ventral tegmental area (VTA). To better understand the underlying causes, synaptic mechanisms were investigated in brain slices from rats. In control tissue, EPSCs displayed concentration-dependent, bimodal responses to CR...
متن کاملThe Metabotropic Glutamate 5 Receptor Modulates Extinction and Reinstatement of Methamphetamine-Seeking in Mice
Methamphetamine (METH) is a highly addictive psychostimulant with no therapeutics registered to assist addicts in discontinuing use. Glutamatergic dysfunction has been implicated in the development and maintenance of addiction. We sought to assess the involvement of the metabotropic glutamate 5 receptor (mGlu5) in behaviours relevant to METH addiction because this receptor has been implicated i...
متن کاملDopamine and Glutamate Interaction Mediates Reinstatement of Drug-Seeking Behavior by Stimulation of the Ventral Subiculum
BACKGROUND Drug addiction is a chronic brain disease characterized by recurrent episodes of relapse to drug-seeking/-taking behaviors. The ventral subiculum, the primary output of the hippocampus, plays a critical role in mediating drug-seeking behavior. METHODS A d-amphetamine intravenous self-administration rat model was employed along with focal electrical stimulation of the ventral subicu...
متن کاملThe Relationship between Glutamate and Multiple Sclerosis
Glutamate is the most important excitatory neurotransmitter in the central nervous system which is involved in synaptic transmission, brain development, synaptic plasticity, learning, and memory. Normally, the enzymatic destruction of glutamate does not occur in the synaptic and extracellular space, but glutamate is removed through specific transporter proteins, leading to stabilization of glut...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Pharmacology
سال: 2009
ISSN: 1471-4892
DOI: 10.1016/j.coph.2008.12.003